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Basic Research on HIV Persistence (R21)

Grant Amount: NIH intends to fund an estimate of 8 awards, corresponding to a total of $2 million, for fiscal year 2015.

The purpose of this initiative is to invite applications that address basic aspects of the persistence of HIV or Simian immunodeficiency virus (SIV) infection in individuals or animals receiving highly active anti-retroviral therapy (HAART). It is expected that applications supported under this FOA will involve at least one of the following areas of study: cellular, structural or systems biology; host and/or viral genetics, immunology, or virology. Research on all aspects of the challenge of so-called latent viral infection is encouraged, including mechanisms responsible for creation, maintenance, and removal of residual viral infection; new assay development; mathematical, cell, and animal model development; and development of new technologies needed to expand the understanding of HIV persistence. Applicants are encouraged to show how proposed studies designed to explore the mechanisms underlying persistence will inform the future investigation and design of therapeutic strategies for long term remission without treatment (functional cure) or complete eradication of persistent virus and achievement of a full cure for HIV infection and AIDS. Applications for R21 awards should describe projects distinct from those supported through the traditional R01 activity code. For example, long-term projects, or projects designed to increase knowledge in a well-established area, will not be considered for R21 awards. Applications submitted to this FOA should be exploratory and novel. These studies should break new ground or extend previous discoveries toward new directions or applications.

This FOA provides support for basic studies needed to advance our understanding of mechanisms of HIV persistence in adults and children. Applicants should propose hypothesis-driven specific aims and directly address one or more of the objectives. The range of responsive research plans may be rather broad; however, the proposed study must potentially lead to a new approach, or improve existing concepts, that could lead to the design of an effective therapeutic strategy for long term remission without treatment (functional cure) or to eradicate viral reservoirs.
Funding Organization
National Institute of Allergy and Infectious Diseases
National Institute on Drug Abuse
Division of AIDS
Eunice Kennedy Shriver National Institute of Child Health and Human Development
US Department of Health and Human Services
Public Health Service
Public Health Services
National Institutes of Health
National Institute of Dental and Craniofacial Research
National Institute of Mental Health
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
NIH intends to fund an estimate of 8 awards, corresponding to a total of $2 million, for fiscal year 2015. Future year amounts will depend on annual appropriations.
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Karl Salzwedel
Phone: (301) 496-5332
Fund Duration
Up to 2 years.
Antiretroviral Drugs
Clinical Research
Research Programs
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed to do otherwise (in this funding opportunity announcement or in a Notice from the NIH Guide for Grants and Contracts). Conformance to the requirements (in the Application Guide and the FOA) is required and strictly enforced. Applicants must read and follow all application instructions noted in Section IV. When the program-specific instructions deviate form those in the application Guide, follow the program-specific instructions. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Companion Funding Opportunity: PAR-14-247, R01 Research Project Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4852

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