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Funding

Tuberculosis Research Units (U19)

Description
Grant Amount: NIAID intends to commit $10 million in FY 2014 to fund two to three TBRUs.

The purpose of this FOA is to support the establishment of two to three multinational, multidisciplinary Tuberculosis Research Units (TBRUs) that will operate as a collaborative network to study tuberculosis latency and persistence and their relation to active TB disease, in humans and animal models. This expansion is expected to facilitate (1) pursuit of separate and distinct avenues of investigation; )2) the ability to target different paucibacillary stages; (3) conduct of both hypothesis-generating and hypothesis-confirming studies; and (4) scientific depth and breadth to address paucibacillary stages of TB disease through integration of human studies and animal models.

Each TBRU will be independently established as part of a multi-disciplinary, multinational consortium of investigators and institutions with expertise in clinical research, animal models, microbiology, epidemiology, immunology, as well as data and statistical management. Each TBRU will be overseen by a Project Director/Principal Investigator (PD/PI) who will coordinate and oversee its multidisciplinary research and ensure that the individual research projects synergize to advance the goals of this FOA. Recognizing that new hypotheses to study human paucibacillary stages of TB may have to be initially developed in animal models and validated in human study cohorts, integration of clinical and animal model research will be required for each TBRU. It is expected that studies conducted through the TBRUs will address key questions that will help to re-define the state of the science in this field and contribute to early stage product development efforts.

Of particular interest for this FOA are immunological studies and biomarker/bio-signature discovery projects to improve strategies for therapeutic, vaccine and diagnostic development. Overall, research conducted under this initiative is expected to provide information about HUMAN TB. All research projects must be clinically relevant. This will necessitate intensive collaborations among clinical and non-clinical researchers to advance this challenging scientific area.

To facilitate the understanding of the spectrum of TB infection and disease and facilitate the translation of research findings into product and clinical applications, each U19 application must include at least one clinical project and one animal research project that synergize to answer critical questions in latency or persistence of TB. Applications that do not include these components will be considered non-responsive and the applications will not be reviewed.



Funding Organization
National Institute of Allergy and Infectious Diseases
Division of Microbiology and Infectious Diseases
Fund Category
TB
Support Types
Cooperative Agreements
Locations
International
National
Eligible Organizations
City Agencies
Colleges/Universities
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
Schools
State Agencies
Tribal Organizations
Number of Awards Given
2 to 3 awards
Award Amount Notes
NIAID intends to commit $10 million in FY 2014 to fund two to three TBRUs.
Applicants may propose budgets of up to $3.25 million total costs (direct and indirect combined) in FY 2014.
Letter of Intent Date
1/14/2013
Application Due Date
2/13/2013
Project Start Date
4/1/2014
Application Contact
GrantsInfo
,
Phone: (301) 435-0714
Technical Contact
Christine Sizemore
Division of Microbiology & Infectious Diseases
NIAID

Phone: (301) 435-2857
Fund Duration
7 years.
Subjects
Clinical Research
Diagnostic Tests
International Cooperation
Medical Treatments and Therapies
Research Programs
TB
TB Prevention
Vaccine Development Research
Audiences
Researchers
Application Process
Applicants are required to prepare applications according to the current PHS 398 application forms in accordance with the PHS 398 Application Guide.

It is critical that applicants follow the instructions in the PHS 398 Application Guide (http://grants.nih.gov/grants/funding/phs398/phs398.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Web Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-12-045.html
Fund Number
RFA-AI-12-045

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN.

cdcnpin.org Fund Record #4598

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