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Funding

Mechanisms of HIV-Related Lung Disease (U01)

Description
Grant Amount: Estimated total of $5,280,000 for fiscal year 2013, with a total cost commitment of $26.4 million over a 5-year period.

The purpose of this funding opportunity announcement (FOA) is to conduct both independent and collaborative research to investigate and define cellular and molecular events underlying the pathogenesis of HIV-associated lung diseases (e.g., COPD and pulmonary hypertension) using biospecimens and clinical data from HIV-infected patients and controls. Clinical translation is encouraged to the extent that it is possible. The goals are to identify disease sub-phenotypes, potential biomarkers to predict risk, progression, and outcome, and molecular targets to help design therapeutic interventions.

Each Clinical/Basic science grant is strongly encouraged to use the multiple Program Director/Principal Investigator (PD/PI) option (http://grants.nih.gov/grants/multi_pi/) to provide strong leadership in basic and clinical pulmonary research and expertise in the clinical management and pathogenesis of HIV infection. It is intended that applications will be multi-disciplinary and highly integrated. The cooperative agreement mechanism of this FOA is intended to facilitate collaborations among the grantees.

This FOA invites investigators with access to HIV-infected patients to leverage their existing resources and conduct independent and collaborative mechanistic research on HIV-related lung disease. It is expected that each application will propose a protocol that can be accomplished at their site alone. It is also expected that each of the Clinical/Basic U01s will participate in at least one collaborative project with other sites funded by this FOA. These collaborative projects may be between two or more sites or they may include all of the sites funded. Applicants must agree to share samples and data for joint projects with other collaborating investigators funded by this FOA.

Applications that utilize existing patient populations and biospecimens are strongly encouraged, however prospective studies on new patients are also permitted. Archival data and biospecimens may be used to enable identification and testing of potential biomarkers and to generate and test hypotheses regarding possible treatment strategies. Applications that propose to collect new samples and data, are expected to set aside de-identified biospecimens and linked data to be stored for possible future use by the wider research community, consistent with achieving the goals of this program. Consent documents are expected to be appropriately worded to allow for sharing of human samples and data among the investigators participating in this FOA and for possible future sharing with other investigators in the larger research community, consistent with achieving the goals of this program.

Funding Organization
National Heart Lung and Blood Institute
Fund Category
HIV/AIDS
Support Types
Cooperative Agreements
Locations
National
Eligible Organizations
City Agencies
Colleges/Universities
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
Schools
State Agencies
Tribal Organizations
Number of Awards Given
8 to 9 awards
Award Amount Notes
The NHLBI intends to fund an estimate of 8-9 awards, corresponding to a total of $5,280,000 for fiscal year 2013, with a total cost commitment of $26.4 million over a 5-year period, but all future year amounts will depend on annual appropriations.
Letter of Intent Date
2/19/2013
Application Due Date
3/19/2013
Project Start Date
9/1/2013
Application Contact
Grants.gov Customer Support
,
Phone: (800) 518-4726
Technical Contact
Hannah H Peavy
Lung Biology and Disease BranchDivision of Lung Diseases
NHLBI
6701 Rockledge Dr. MSC 7952
Bethesda, MD 208927952
Phone: (301) 435-0222
Fax: (301) 480-3557
Fund Duration
5 years.
Subjects
Clinical Research
HIV
HIV Positive Persons
Information Dissemination
Audiences
Information Providers
Researchers
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Notes
Companion Funding Opportunity: RFA-HL-13-028, U01 Research Project – Cooperative Agreements.
Web Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-13-026.html
Fund Number
RFA-HL-13-026

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN.

cdcnpin.org Fund Record #4611

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