Mechanisms of Cellular Immunity in the Female Reproductive Tract (R01)
Grant Amount: NIAID intends to commit $ 2M in FY 2014.
The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research focused on the discovery of mechanisms that mediate effective antigen-specific memory T cell responses in the female reproductive tract (FRT). The ultimate goal is to develop the knowledge base needed to develop future vaccines that elicit effective and durable T cell responses against infection by HIV and other viral pathogens in the FRT. This FOA is intended to support innovative basic research efforts and is not intended to support the preclinical or clinical development of vaccine candidates or adjuvants. A similar concept was previously released as PA-12-104, and applicants are urged to read this FOA carefully, since there are differences that could alter responsiveness. Investigators with the appropriate expertise, but not currently in the HIV field are encouraged to apply.
While previous research has generated a great deal of information about HIV and SIV T cell responses during infection in humans or non-human primates, there is a significant gap in our understanding of the establishment, trafficking, maintenance and function of memory T cells at the portals of viral entry. Therefore, this FOA solicits basic research applications that seek to contribute to the understanding of how to generate effective and persistent T cell responses against infection by HIV and other viral pathogens in the FRT. Applicants are strongly encouraged to focus on the study of Tem populations that could rapidly eliminate or control viral infection. Investigators with the appropriate expertise, but not currently in the HIV field are encouraged to apply.
National Institute of Allergy and Infectious Diseases Division of Intramural Research
City Agencies Colleges/Universities Commercial Organizations Community Based Organizations County Agencies Educational Organizations/Institutions Federal Government Agencies International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations Religious Organizations Schools State Agencies Tribal Organizations
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
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