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Tuberculosis Outbreak Prevention Feasibility Project

Grant Amount: Approximate Total Fiscal Year Funding: $100,000; Approximate Total Project Period Funding: $100,000.

During 2002-2011, CDC assisted with the investigation of 40 tuberculosis (TB) outbreaks involving 647 cases 32 deaths. Early identification and investigation of TB clusters that are likely to become outbreaks has the potential to have a substantial impact on preventing outbreaks by interrupting disease transmission, thereby and making progress toward TB elimination in the United States. Recent research has identified an algorithm to predict which TB genotype clusters are likely to become outbreaks (Althomsons et al, 2012). In order to determine whether it is feasible to develop a national program for intervening with these high-risk clusters and preventing outbreaks, a clear process must be developed for: applying the algorithm using real-world data; performing a comprehensive investigation to identify all persons involved in the cluster; and intervening in the cluster to maximize the number of infected persons that complete treatment.
CDC and the awardee of the Cooperative Agreement will collaborate through this feasibility project to develop a process for intervening with small TB clusters that have a high likelihood of becoming outbreaks, thereby preventing outbreaks from occurring. The outcomes of the project will include a report of tools, strategies, and processes that can be used to detect, investigate, and intervene with clusters at high risk of becoming outbreaks (outbreak prevention investigation and intervention process report/protocol) and a written summary of the amount of monetary and personnel resources used to investigate and intervene with the cluster.
The four phases (or program strategies) of this feasibility project include cluster detection, cluster investigation, intervention, and documentation/process development; candidate clusters will be included in all phases. A minimum of one and maximum of three candidate clusters will be included.
Cluster detection will start at the onset of the project period based on the algorithm published by Althomsons et al (2012); however, the cluster investigation and intervention phases can only start once a candidate cluster has been identified. Therefore, the timelines in this project will be presented in reference to the date of cluster detection rather than the start of the cooperative agreement.
The awardee may start with the initial list of specific strategies/activities in the “toolboxes” developed by CDC, but are expected to add to these throughout the course of the project based on own experience and published evidence from the peer-reviewed literature. The awardee is expected to actively work with CDC throughout the process and in development of the products.
Funding Organization
US Department of Health and Human Services
Public Health Service
Centers for Disease Control and Prevention
Fund Category
Support Types
Cooperative Agreements
Eligible Organizations
State Agencies
Award Date
Number of Awards Given
1 award
Maximum Amount
Average Amount
Award Amount Notes
Approximate Total Fiscal Year Funding: $100,000.
Approximate Total Project Period Funding: $100,000.
Application Due Date
Application Contact
Technical Information Management
CDC Procurement & Grants Office
2920 Brandywine Road, MS E-14
Atlanta, GA 30341
Phone: (770) 488-2700
Technical Contact
Lee A Ramsey
Project Officer
1600 Clifton Road, MS E-10

Phone: (404) 629-2429
Fund Duration
1 year.
Program Development
TB Prevention
Health Planners
State Government Agencies
Application Process
Registering your organization through, the official HHS E-grant website, is the first step in submitting an application online. Registration information is located on the “Get Registered” screen of

All applicant organizations must register with The “one-time” registration process will take three to five days to complete. However, it is best to start the registration process as early as possible.

Applicants must download the SF-424 application package associated with this funding opportunity from If access to the Internet is not available or if the applicant encounters difficulty in accessing the forms online, contact the HHS/CDC Procurement and Grant Office Technical Information Management Section (PGO TIMS) staff at (770) 488-2700 for further instruction. CDC Telecommunications for individuals with hearing loss is available at: TTY 1.888.232.6348.
Web Site;jsessionid=NrKQRQSdgJT8TrLhwzKhJh1R1j9WRTgsKZkCwQ2GqKNlSGSZgpHJ!828092678?oppId=227045&mode=VIEW
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4680

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