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Symptom Management in HIV-Infected Individuals with Comorbid Conditions (R21)

Grant Amount: Unspecified.

This funding opportunity announcement (FOA) is seeking research focused on development, adaptation, or testing interventions aimed at identifying and managing symptoms related to HIV-Associated Non-AIDS (HANA) conditions, specifically functional capacity and frailty and increasing resilience (self-care) of HIV-infected persons with HANA.

A secondary purpose of this initiative is to develop a better understanding of the needs of caregivers of the aging person with HIV/AIDS and to consider methods to reduce their stress as they provide care. The objectives of this FOA include but are not limited to:

Assess the effects of symptoms associated with daily function and frailty on comorbid conditions in PLWHA (differentiated by gender, race/ethnicity, and culture);
Examine the relationships among functional capacity, symptoms and behavior in PLWHA;
Develop and test interventions aimed at increasing functional capacity and resilience and decreasing frailty in PLWHA;
Assess the impact of decreased functional capacity on caregivers of PLWHA.

The R21 mechanism is intended to encourage new exploratory and developmental research projects. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area, will not be considered for R21 awards. Applications submitted under this mechanism should be exploratory and novel. These studies should break new ground or extend previous discoveries toward new directions or applications.
Funding Organization
US Department of Health and Human Services
Public Health Service
National Institutes of Health
National Institute of Nursing Research
Fund Category
Support Types
Eligible Organizations
City Agencies
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
State Agencies
Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Application Due Date
Project Start Date
Application Contact
Phone: (301) 435-0714
Technical Contact
Lynda Hardy
Phone: (301) 594-5976
Fund Duration
Up to 2 years.
Behavioral Research
HIV Positive Persons
Patient Care
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (, except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
For AIDS Application due date, visit:

Companion Funding Opportunity PA-13-210, R01 Research Project Grant.
Web Site
Fund Number

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN. Fund Record #4704

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