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Funding

Targeting Latently Infected Cells Without Reactivation (R01)

Description
Grant Amount: NIAID intends to commit $2.7 million in FY2015 to fund 4-7 awards.

The purpose of this Funding Opportunity Announcement (FOA) is to solicit innovative research that advances the understanding of mechanisms or approaches that could be harnessed to selectively eliminate HIV-1 latently-infected cells without depending on viral reactivation. The ultimate goal is to inform the design of future therapeutic approaches that could be used to eradicate the latent reservoir that persists in the context of optimally suppressive highly active antiretroviral therapy (HAART), thereby affecting a permanent cure for HIV infection. Cross-disciplinary collaborations enabling technology-driven strategies are strongly encouraged.

As opposed to the creation of more effective strategies to reactivate latent provirus or to develop strategies to eliminate cells expressing viral proteins, the purpose of this Funding Opportunity Announcement (FOA) is to stimulate highly innovative research to advance the understanding of mechanisms or approaches that could be harnessed to selectively eliminate HIV-1 latently-infected cells without depending on viral reactivation or viral protein expression. The ultimate goal is to inform the design of future therapeutic approaches to cure HIV infection that do not require reversing latency. In order to move toward this goal, this FOA is focused on the following three objectives:

(1) Identification of biomarkers/molecular signatures of latently-infected cells that could be used to selectively target and kill cells harboring latent HIV-1 DNA;
(2) Novel approaches to selectively eliminate latently-infected cells that do not require reactivation or HIV gene expression;
(3) Approaches to permanently inactivate integrated HIV provirus.

Due to the inherent complexity of the latent reservoir, applications that leverage cross-disciplinary collaborations to apply cutting-edge technologies are especially encouraged.

For the purposes of this FOA, a latent viral reservoir is defined as an infected cell population that allows for the indefinite persistence of replication-competent HIV-1 in patients on optimal HAART regimens.
Funding Organization
National Institute of Allergy and Infectious Diseases
Division of AIDS
Fund Category
HIV/AIDS
Support Types
Research
Locations
International
National
Eligible Organizations
City Agencies
Colleges/Universities
Commercial Organizations
Community Based Organizations
County Agencies
Educational Organizations/Institutions
Federal Government Agencies
International Agencies
IRS 501 (c)(3) Organizations
Nonprofit Organizations
Religious Organizations
Schools
State Agencies
Tribal Organizations
Number of Awards Given
4 to 7 awards
Award Amount Notes
NIAID intends to commit $2.7 million in FY2015 to fund 4-7 awards.
Letter of Intent Date
6/15/2014
Application Due Date
7/15/2014
Project Start Date
3/1/2015
Application Contact
GrantsInfo
,
Phone: (301) 435-0714
Technical Contact
Alan Embry
NIAID
Phone: (301) 435-3751
Fund Duration
Up to 5 years.
Subjects
Antiretroviral Drugs
HIV/AIDS Prevention
Medical Treatments and Therapies
Research Programs
Audiences
Researchers
Application Process
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.

It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
Web Site
http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-021.html
Fund Number
RFA-AI-14-021

Disclaimer: NPIN provides this information as a public service only. The views and information provided about the materials, funding opportunities, and organizations do not necessarily state or reflect those of the U.S. Department of Health and Human Services, CDC, or NPIN.

cdcnpin.org Fund Record #4823

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