HIV Vaccine Vector-Host Interactions: Understanding the Biology and Immunology (R01)
Grant Amount: Unspecified.
The purpose of this Funding Opportunity Announcement (FOA) is to develop an increased understanding of the biology and immunology of natural viral infections and HIV vaccine vectors derived from these viruses. Applications should focus on four types of vaccine viral vector platforms developed from Adenoviridae, Poxviridae, Herpesviridae, and Adeno-associated viruses in humans or non-human primates (NHPs). It is anticipated that this research may lead to clearer understanding of vector-host interactions and therefore, a reduction in unanticipated adverse events associated with uncharacterized host-vector interactions. Goals of the research can also include the development of improved safety models to assess the potential vaccine-related effects such as increased HIV infection rates due to immune activated vector-specific HIV target cells (e.g. CD4+ T-cells, etc.). Such animal models (e.g., NHP, humanized mouse models, etc.) must be capable of quantitatively assessing the potential for increased HIV acquisition following vaccination to permit better preclinical assessment of future vaccines candidates. This research would inform earlier decisions on safety related to potential vaccine-related effects.
This initiative is intended to advance understanding of 1) the biology and immune response to live attenuated or replication-defective viral vectors developed from Adenoviridae, Poxviridae, Adeno-associated viruses, and Herpesviridae families in humans and NHPs, and 2) the development of animal models (e.g., NHP, humanized mouse models, etc.) that could better evaluate the potential for increased HIV acquisition following vaccination.
National Institute of Allergy and Infectious Diseases Division of Intramural Research
City Agencies Colleges/Universities Commercial Organizations Community Based Organizations County Agencies Educational Organizations/Institutions Federal Government Agencies International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations Religious Organizations Schools State Agencies Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
HIV Research Programs Vaccine Development Research
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
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