B Cell Help Immunology Program for AIDS Vaccine Strategies (R01)
Grant Amount: Unspecified.
The purpose of this Funding Opportunity Announcement (FOA) is to: (1) support multidisciplinary projects that define the role(s) played by innate immunity and T cells in shaping the B cell response to HIV-1 antigens; and (2) identify strategies to modulate innate immune mechanisms and T cell differentiation pathways to optimize B cell helper functions for enhancing HIV-1 vaccines and generating long-term memory.
The objectives of the BCHIP for HIV-1 Vaccine Design are to support: (1) innovative studies that identify new immunization strategies to induce protective persistent antibody; and (2) studies that increase fundamental knowledge of the immunological mechanisms involved in the induction and regulation of B cell immune responses leading to protective HIV-1 antibody responses, both systemically and in the mucosa.
Due to the complexity of generating protective humoral responses to HIV-1, applications that leverage multidisciplinary collaborations in synergistic basic discovery research in immunology, virology and host genetics are encouraged. These collaborations may comprise the translation of existing critical knowledge and technologies from other fields for the benefit of HIV-1 vaccine design. Translation of the proposed hypothesis into immunogen design and/or immunization strategies for evaluation in animal models is encouraged.
National Institute of Allergy and Infectious Diseases Division of Intramural Research
City Agencies Colleges/Universities Commercial Organizations Community Based Organizations County Agencies Educational Organizations/Institutions Federal Government Agencies International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations Religious Organizations Schools State Agencies Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
AIDS HIV Research Programs Vaccine Development Research
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
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