NK Cells to Induce Immunological Memory to Prevent HIV Infection (R01)
Grant Amount: Unspecified.
This Funding Opportunity Announcement (FOA) invites applications to study the immunomodulatory or effector roles of Natural Killer (NK) cells in facilitating and/or regulating the antiviral adaptive immune responses in the context of HIV-1 vaccines. The outcome of these research projects should provide novel approaches to harness NK cell immunoregulatory function in HIV-1 vaccine design and also to enhance protective HIV-1 specific adaptive immune responses.
The primary objective of this funding opportunity is to support multidisciplinary, hypothesis-driven research on NK cells, leading to the discovery of pathways relevant to early immune responses and immune regulation impacting the sought-for protective immunity induced by HIV vaccination. Secondary objectives include the development of novel technologies to allow for more systematic and robust studies of human innate system monitoring in the context of vaccine clinical trials and to enable the recruitment of innate immunologists to the HIV vaccine field.
This initiative will support research to understand the early events triggered by vectored and/or adjuvanted HIV vaccines and the impact of vaccination on the effector/immunoregulatory balance of NK cells.
National Institute of Allergy and Infectious Diseases Division of Intramural Research
City Agencies Colleges/Universities Commercial Organizations Community Based Organizations County Agencies Educational Organizations/Institutions Federal Government Agencies International Agencies IRS 501 (c)(3) Organizations Nonprofit Organizations Religious Organizations Schools State Agencies Tribal Organizations
Award Amount Notes
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
HIV/AIDS Prevention Research Programs Vaccine Development Research
Applicants must download the SF424 (R&R) application package associated with this funding opportunity using the “Apply for Grant Electronically” button in this FOA or following the directions provided at Grants.gov.
It is critical that applicants follow the instructions in the SF424 (R&R) Application Guide (http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_General_Adobe_VerB.pdf), except where instructed in this funding opportunity announcement to do otherwise. Conformance to the requirements in the Application Guide is required and strictly enforced. Applications that are out of compliance with these instructions may be delayed or not accepted for review.
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